Greeting

Thanks so much for visiting our website. The research project “Supramolecular Behavior and Dynamic Capture of MetaAggregates” in Grant-in-Aid for Transformative Research Areaｓ(B) began in April 2023.

　In vitro, the aggregation of amyloids is explained by a template-dependent mechanism based on monomeric structures. However, in a biological environment, unlike in test tubes, it has become evident that they co-aggregate with other biomolecules present in the same location. One of the reasons why drug discovery strategies targeting amyloid aggregates in neurodegenerative diseases have not shown decisive effects is probably the varying discrepancy between these contrasting environments. In this study, therefore, we have defined these heterogeneous aggregates that exist as toxic entities and exhibit supramolecular behavior through co-aggregation with other biomolecules as “MetaAggregates.” By analyzing the interactions with different amyloids, nucleic acids, and proteins from a panoramic perspective (MetaView) in particular, We hope that we can bring about a profound transformation in the supramolecular chemistry research of amyloids.

　Our ultimate goal is the “fundamental treatment for neurodegenerative diseases,” which would be a world first. We would like to spread significance and awareness of this research field to many people and expand the circle of collaboration from basic research to applications. We are especially looking forward to the broader participation of young scientific researchers worldwide, so let’s gather together and join forces in MetaAggregate!